STUDY OF MORPHOLOGY AND HISTOLOGY OF PLACENTA IN HYPERSENSITIVE MOTHERS

Background: Hypertensive pregnancy may be responsible for vascular damage, enhanced systemic inflammation and insulin resistance in the placenta as oxygen nutrient transfer is impaired oxidative stress generated affecting placental growth development. Placental pattern hypertensive pregnancies shows a variable owing to insufficiency. Method: The study was carried out on 80 sets placentae, mothers their babies. placentae were collected from Obstetrics & Gynecology Department of NSCB Medical College Jabalpur. Out 40 normal pregnant complicated by PIH previously normotensive women, serial number mother baby same. soon after vaginal delivery or caesarian section along with 10 cm long stump umbilical cord. Aims objectives: aim this determine whether maternal would affect morphology histology compare that mothers. It cross-sectional comparative at maternity ward anatomy department College, Result: A Macroscopic revealed weight, volume, diameter, thickness cotyledons less group. Mean weight group 336gm control 425 (p<0.05). volume 236and352 ml respectively 14.7and 16 but not significant mean diameter15.6 cms and17.05cms But present (p<0.539). There single artery one patient All morphometric parameters thickness, no. reduced.
 Histological findings cytotrophoblastic cellular proliferation, syncitial knot formation, fibrin plaque formation. In 20 percent cases, villi hypovascular. hypovascular have abundance knots, usually lack vasculosyncitial membrane increased stromal collagen. Conclusion: adversely both placenta.
 Keywords: morphology, histology, placenta, hypersensitive